week 1 disc 2 reply to Samantha R

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Cell morphology, defined as the study of cellular shape and structure, is a fundamental principle of cellular biology. It plays an important role in determining a cells general function and structure. The shape of a cell is closely linked to its specialized function, with adaptions that help optimize efficiency. Red blood cells are biconcave discs designed to maximize oxygen transport, while nerve cells have elongated structures to enhance signal transmission. Cell morphology is interconnected with the cytoskeleton, a complex network of proteins that maintains shape, offers mechanical support, and facilitates cellular movement (Dlugasch & Story, 2021).

Case Study

I am going to address the case study of a 15 year old male who presents after ingesting windshield wiper fluid to get high. According to Inman et al. (2023), windshield wiper fluid is methanol and is considered a toxic alcohol. The ingestion of such chemicals has a significant mortality rate since metabolism ultimately leads to formaldehyde and formic acid which can disrupt cell osmolarity. Once this patient ingested the methanol, his body started attempting to metabolize it, leading to the accumulation of these toxic metabolites which then affects cell osmolarity. Early after toxic alcohol ingestion, the patient will have an elevated osmolar gap (Inman et al., 2023), When it comes to the sodium levels, methanol itself does not directly impact sodium levels, but the toxic metabolites produced during its metabolism, such as formic acid, can lead to acidosis, which may indirectly influence sodium levels. Methanol is metabolized in the body to formaldehyde and then to formic acid. The accumulation of formic acid can lead to metabolic acidosis, where there is an excess of acid in the body. In response to the acidosis, the body may attempt to buffer the excess acid by shifting hydrogen ions (H+) into cells and extruding sodium ions (Na+) from cells to maintain electrical neutrality which can lead to lower sodium levels in the extracellular fluid. Acidosis influences the osmotic pressure in the blood. When the blood becomes more acidic, the body may shift hydrogen ions into cells and extrude cations like sodium (Na+) out of cells to maintain electrical neutrality. This shift or ions affect the osmotic pressure within cells and the extracellular fluid. It can lead to changes in the distribution of water between compartments, which can affect osmotic pressure. Methanol poisoning can also lead to vomiting, diarrhea, and respiratory disturbances, which can result in dehydration which can then in turn affect the concentration of solutes and ions in the blood, contributing to osmotic pressure changes (Ashurst & Nappe, 2023)

References

Ashurst, J.V., & Nappe, T.M. (2023). Methanol toxicity. In: StatPearls [Internet]. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK482121/

Dlugasch, L., & Story, L. (2021). Applied pathophysiology for the advanced practice nurse. Jones and Bartlett Learning.

Inman, B., Maddry, J.K., Ng, P.C, Koyfman, A., Long, B. (2023). High risk and low prevalence diseases: toxic alcohol ingestion. The American Journal of Emergency Medicine, 67(1), 29-36. https://www.doi.org/10.1016/j.ajem.2023.01.048

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